Upbit → Bybit 송금하기; 14:26

• Tron으로 옮김. 송금 수수료 없음. 한 5분 걸림. 365.31 USD

환경부 과제

Jon A. Arnot, et al. SETAC PRESS, 2008.

• BCF: Chemical exposure from water under controlled laboratory conditions

• BAF: Chemical exposure from water and diet as occurs in the environment

• Although the routes of exposure differ, both endpoints depend on the same chemical elimination processes (gill ventilation, fecal egestion, metabolic biotransformation, and growth dilution).

• QSAR, mechanistic mass balance bioaccumulation models of organisms and food webs를 사용하여 진행해야함.

• Mass balance method를 통해 k_M값을 추정함.

• $k_\mathrm{total} := k_\mathrm{physical} + k_\mathrm{M}$

  $\Leftrightarrow k_\mathrm{M} = k_\mathrm{total} - k_\mathrm{physical}$

• Cf = 3이라면 예상되는 k_M 값이 추정값의 1/3~3배 사이에 있을 확률이 95%라는 것.

• 일단, BCF, k_T, half-life data를 다양한 곳에서 모음.

$k_\mathrm{M, N} = k_\mathrm{M,i}\left(\frac{W_\mathrm{N}}{W_\mathrm{i}}\right)^{-0.25}\exp[0.01(T_\mathrm{N}-T_\mathrm{i})]$

W_N = 0.01 kg, T_N = 15°C

• Weight and temperature values used for normalization were selected to represent the approximate median values of these parameters in the database.
• The maximum k_M values based on hepatic rates ranged from 1.5 (log Kow > 4) to 7.5 per day (log Kow = 0) - 1 kg at 10°C
• 9.5 to 48.9 per day - 1 g at 25°C
• The possibility of extrahepatic biotransformation, particularly for phase II pathways, and the uncertainty of protein-binding estimates were also discussed.
• In vitro studies have shown that enzymatic activity in extrahepatic tissues (kidney, gill, blood, and muscle) can approximate the enzymatic activity of the liver in some cases; however, this is variable and uncertain.
• Bioaccumulation 평가를 위해서는 Kow, BCF, BAF를 기반으로 함.
• BAF/BCF는 노출의 경로는 다르더라도 동일한 제거 과정에 의존함.

Economist

• It also proposes that people in custody awaiting trial should no longer be allowed to wear their own clothes or eat non-prison food.
  • Trial: 재판
  • Custody: 구금, 보호